(2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate
CAS: 203866-16-4
Molecular Formula: C11H18FNO4
(2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester - Names and Identifiers
| Name | 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate |
| Synonyms | N-Boc-cis-4-Fluoro-L-proline methyl ester N-t-BOC-cis-4-fluoro-L-proline methyl ester Ethyl (2S,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline Methyl ester (2S)-1-tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate 1-tert-butyl 2-Methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester |
| CAS | 203866-16-4 |
| InChI | InChI=1/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8-/m0/s1 |
| InChIKey | METPQQHVRNLTRX-YUMQZZPRSA-N |
(2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester - Physico-chemical Properties
| Molecular Formula | C11H18FNO4 |
| Molar Mass | 247.26 |
| Density | 1.153 |
| Melting Point | 210 °C |
| Boling Point | 296.5±40.0 °C(Predicted) |
| Specific Rotation(α) | -67o (C=0.5 IN METHANOL) |
| Flash Point | 110℃ |
| Vapor Presure | 0.001mmHg at 25°C |
| pKa | -5.68±0.60(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.448 |
(2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester - Risk and Safety
| WGK Germany | 2 |
(2S,4S)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester - Introduction
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is a common compound in organic synthesis, and its chemical formula is C12H18FNO4. The following is a description of some properties, uses, preparation and safety information about this compound:
Nature:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is a colorless to light yellow solid with a low melting point and boiling point. It is stable at room temperature, but may decompose under high temperature and strong acid conditions.
Use:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is widely used in organic synthesis, especially in the field of peptide synthesis. It is often used as a protecting group to protect amine groups in amino acids to prevent unwanted changes in synthetic reactions. In addition, it can also be used as an important synthetic intermediate for the preparation of other related compounds.
Method:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is usually prepared by chemical synthesis. A common method is to use boc-cis-4-fluoro-l-proline as the starting material to obtain the desired product by esterification reaction with methyl formate under basic conditions.
Safety Information:
When using or handling 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, note the following safety precautions:
1. Avoid contact with skin, eyes and respiratory tract, and wear appropriate protective equipment during use.
2. During operation, Good Laboratory safety practices should be observed to ensure good ventilation conditions.
3. Avoid the compound and combustible, strong oxidant and strong acid and other substances contact, to prevent dangerous reaction.
4. When storing, the compound should be sealed and stored in a cool, dry place, away from fire and heat sources.
5. When disposing of waste, it should be properly disposed of in accordance with local regulations.
Please note that this is only a general introduction to 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, the specific operation and use details should be further understood and implemented according to the actual situation and relevant literature.
Nature:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is a colorless to light yellow solid with a low melting point and boiling point. It is stable at room temperature, but may decompose under high temperature and strong acid conditions.
Use:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is widely used in organic synthesis, especially in the field of peptide synthesis. It is often used as a protecting group to protect amine groups in amino acids to prevent unwanted changes in synthetic reactions. In addition, it can also be used as an important synthetic intermediate for the preparation of other related compounds.
Method:
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate is usually prepared by chemical synthesis. A common method is to use boc-cis-4-fluoro-l-proline as the starting material to obtain the desired product by esterification reaction with methyl formate under basic conditions.
Safety Information:
When using or handling 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, note the following safety precautions:
1. Avoid contact with skin, eyes and respiratory tract, and wear appropriate protective equipment during use.
2. During operation, Good Laboratory safety practices should be observed to ensure good ventilation conditions.
3. Avoid the compound and combustible, strong oxidant and strong acid and other substances contact, to prevent dangerous reaction.
4. When storing, the compound should be sealed and stored in a cool, dry place, away from fire and heat sources.
5. When disposing of waste, it should be properly disposed of in accordance with local regulations.
Please note that this is only a general introduction to 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate, the specific operation and use details should be further understood and implemented according to the actual situation and relevant literature.
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: N-Boc-cis-4-Fluoro-L-proline methyl ester Visit Supplier Webpage Request for quotation
CAS: 203866-16-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 203866-16-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: N-Boc-cis-4-Fluoro-L-proline methyl ester Visit Supplier Webpage Request for quotation
CAS: 203866-16-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 203866-16-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History